Guiao has eyes on Standhardinger, Ravena as NLEX’s draft pick

first_imgGuiao also had nothing but praise for the 23-year-old Ravena, who won two UAAP titles and a couple of UAAP MVPs with Ateneo“Kiefer, on the other hand, we all know that he can be a go-to guy, he can also create for his teammates, he has leadership. He’s not afraid to take over a game. He’s a very intelligent, high-IQ player, so those are the things that a team like ours could really need.” China Kashgar ousts Chooks-to-Go from title contention with 16-point beatdown Christian Standhardinger. Photo from Fiba.comNLEX will most likely pick second overall in the 2017 PBA Draft that has head coach Yeng Guiao licking his chops given the potential of talents that would be available.So far, only Christian Standhardinger has officially applied for the draft among the highly-touted prospects eyeing to make the jump to the pros this year.ADVERTISEMENT MOST READ Read Next LOOK: Loisa Andalio, Ronnie Alonte unwind in Amanpulo for 3rd anniversary Guiao both described Standhardinger and Ravena as “immediate impact players.”He likes the fact that Standhardinger is a seasoned player having played in Basketball Bundesliga, a top tier professional club league in Germany.“Standhardinger is coming into the draft at 28 years old, he’s mature. He’s got experience, so you don’t need to put him through a learning process,” said Guiao.“He understands the game from what we’ve seen. He’s a hard worker, he can fit right into any team’s system.”The 6-foot-7 Fil-German introduced himself to Philippine basketball when he was tapped to play for the national team in the Jones Cup before suiting up as Gilas Pilipinas’ naturalized player in the 2017 Fiba Asia Cup as a replacement for Andray Blatche.ADVERTISEMENT Typhoon Kammuri accelerates, gains strength en route to PH Frontrow holds fun run to raise funds for young cancer patients  Fire hits houses in Mandaluyong City Fire hits houses in Mandaluyong City View comments But the likes of Kiefer Ravena, Jeron Teng and other big names could also follow suit.Most coaches keep their cards close to their chest but Guiao didn’t beat around the bush when asked who intends to select.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutout“Nothing but the obvious so if Standhardinger is No. 1, maybe we’ll go with Kiefer. If it’s Kiefer’s No. 1 then we’ll go with Standhardinger because most likely we’ll be No. 2, so it’s really that obvious, I guess,” said Guiao.“We have another draft very early in the second round so we’ll see who are the best available talent in the second round.” Brace for potentially devastating typhoon approaching PH – NDRRMC BSP sees higher prices in November, but expects stronger peso, low rice costs to put up fight Trending Articles PLAY LIST 00:50Trending Articles00:50Trending Articles00:50Trending Articles01:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games Nonong Araneta re-elected as PFF president Don’t miss out on the latest news and information. LATEST STORIESlast_img read more

a month agoVitesse coach Slutsky: Today’s footballers should be grateful to Abramovich

first_imgTagsTransfersAbout the authorPaul VegasShare the loveHave your say Vitesse coach Slutsky: Today’s footballers should be grateful to Abramovichby Paul Vegasa month agoSend to a friendShare the loveVitesse Arnhem coach Leonid Slutsky says today’s footballers across Europe should be grateful to Roman Abramovich.Slutsky, who is close to the Russian billionaire, argues football’s wage explosion would not have happened without Abramovich buying Chelsea.He stated: “Abramovich is a revolutionary in world football.”All the young players of our time should say thanks to Roman Abramovich, who, by joining football, raised the salary level several times. “Now you will not surprise anyone with huge salaries, but Abramovich started everything.”Abramovich has owned Chelsea since the summer of 2003. last_img read more

TransCanada to change name to TC Energy

first_imgNEW YORK — TransCanada Corp., the company behind the contentious Keystone XL oil pipeline, is changing its name to TC Energy.If approved by shareholders and regulators, TransCanada becomes TC Energy in the second quarter. The stock ticker “TRP” will not change.The Keystone XL project is being delayed by a federal court that found the Trump Administration didn’t fully consider the environmental effects when it approved the permit for the 1,184-mile (1,900 kilometre) pipeline, intended to ship up to 830,000 barrels a day of crude oil from Alberta, Canada to the U.S. Gulf Coast.The project has been marred by protests. Environmentalists and Native American groups had sued to stop the pipeline, citing property rights and possible spillsA hearing on the proposed pipeline is scheduled for Monday in Great Falls, Montana.The Associated Presslast_img read more

Ralf Bartoleit ProSiebenSat1 Digitals comanagin

first_imgRalf BartoleitProSiebenSat.1 Digital’s co-managing director Ralf Bartoleit is taking the top job at video-on-demand service Maxdome in addition to his current duties.ProSiebenSat.1 confirmed that Bartoleit will take over from Maxdome CEO Marvin Lange, who is leaving the company after four years.Lange only recently became sole chief executive of ProSiebenSat.1 Media-owned Maxdome following an internal reshuffle that was announced in February.He was previously co-CEO of Maxdome along with Filmon Zerai, but took full charge of the service when Zerai took the newly created role of chief digital officer at ProSiebenSat.1 TV Germany on March 1.Bartoleit has held various management positions at ProSiebenSat.1 since 2005. His new joint role as CEO of Maxdome and co-MD at ProSiebenSat.1 Digital will see ProSiebenSat.1 more closely integrate the video site into its group-wide video and distribution strategy.last_img read more

Both the Guildhall and Tower Museum have been comm

first_imgBoth the Guildhall and Tower Museum have been commended for their commitment to ensure that services are open to all. Staff and volunteers at both venues also recently completed the full day workshop on fundamentals of autism and as a result were acknowledged as ‘Autism Champions’. They have also been presented with a plague for their achievements in becoming ‘autism-friendly’ venues.Congratulating all involved on the completion of training and the adaptions to the Guildhall and Tower Museum, Access and Inclusion Coordinator at DCSDC, Louise Boyce said: AUTISM NI have awarded the Guildhall & Tower Museum the prestigious ‘Autism Impact Award’ in recognition of the venues going ‘above and beyond’ to create accessible and ‘autism-friendly’ environments.They are two out of 21 cultural venues in the Derry City and Strabane District Council area to achieve the award with support from the Public Health Agency.Council is also taking a pro-active approach towards encouraging arts & cultural venues across the City and District to do what they can to make their premises more autism-friendly. “It’s great to see the staff from the Guildhall and Tower Museum recognised as ‘Autism Champions’ and receiving the prestigious ‘Autism Impact Award’.“The work being led and implemented by Council through the Access and Inclusion Project is encouraging arts and cultural venues across the City and District to continuously work towards becoming more autism-friendly.“It is a real testament from all the team who understand the importance and impact on achieving such an award and I would like to warmly congratulate the Guildhall and Tower Museum for doing so.”Christine English, Autism NI’s Development Manager said: “We are delighted to work in partnership with Derry City and Strabane District Council as they work to become an Autism-Friendly Council.“Autism NI have been working with the Council’s Culture Section for over a year as part of the ‘Access and Inclusion Project’ to provide training and support to a number of venues through our Impact Award Scheme, which awards and celebrates organisations who are committed to Autism Accessibility.“We congratulate the Guildhall and Tower Museum on being two of the first venues in the area to achieve this award and look forward to continuing this great partnership to increase accessibility in other venues across the Council.”For further information on DCSDC’S Access and Inclusion Programme please or telephone: 02871 253 253 extension 4349. TEXTPHONE: 02871376 646.Guildhall & Tower Museum receive Autism Impact Award was last modified: January 30th, 2019 by John2John2 Tags: Autism NIDerry and Strabane CouncilGuildhall & Tower Museum receive Autism Impact AwardLOUISE BRESLINMayor John Boyle ShareTweetlast_img read more

Make Big Oil Pay For Your Retirement Oil fat cat

first_imgMake “Big Oil” Pay For Your RetirementOil fat cats get rich on $4 gas.Now how’d you like to make them pay you back?This little-known “loophole” let’s you collect up to triple the retirement income most stocks or bonds pay… without touching the stock market… and all while “Big Oil” gets stuck with the bill.Click here now for all the details. Sponsor Advertisement It’s impossible to tell whether the price rallies during the New York trading session yesterday were short covering or new longs being placed.Gold traded very quietly in the Far East and early London trading.  The low, such as it was, came just after 12 o’clock noon in London…and by 11:00 a.m. in New York four hours later, gold was back to unchanged from Friday’s close.Then the gold price popped about fifteen bucks or so…hitting its high of the day, $1,589.50 spot, just minutes before the Comex close.  From there it got sold down a few dollars going into the electronic trading session.Gold closed at $1,585.30 spot…up an even $13 on the day.  Volume, which had been exceedingly light up until that price jump, soared all the way up to around 114,000 contracts net.The silver price made another attempt to break through the $27 spot price mark the moment that the market opened on Sunday night in New York, but that got sold down 40 cents in pretty short order.  Silver the rose back to unchanged about 2:00 p.m. Hong Kong time…and it slid to its London low at the 12:00 o’clock noon silver fix.The subsequent rally lasted until 11:15 a.m. in New York, making it all the way back to Friday’s closing price.  Then the silver price rose rapidly from there…and most of the significant gains were in by shortly after 12 o’clock noon in New York.  Silver moved a bit higher from there, with the high of the day [27.77 spot] coming about five minutes before the Comex closed.From that high, silver got sold off about two bits…and closed at $27.54 spot…up 64 cents on the day.  Gross volume was huge…but net volume was pretty light at around 24,000 contracts.  Silver had an intraday price move of about $1.17…or 4.35% to the upside.The dollar index rallied a bit yesterday, hitting its high tick of the day…about half-past lunchtime in London, which was 7:30 a.m. Eastern.  After that, it gave up about half its gains…and finished the Monday session in New York up about 20 basis points.The gold stocks started off slowly…and finally broke into positive territory to stay on the gold price run-up in the last hour of trading yesterday morning.  The high of the day for the HUI was around 1:30 p.m. Eastern…and it faded a hair into the close…but finished up 1.12% on the day.The silver stocks were a mixed bag yesterday, but there were more green arrows than red ones…and Nick Laird’s Silver Sentiment Index closed up a tiny 0.16%.(Click on image to enlarge)Considering that the equity markets in general did so poorly, I’m grateful for the gains that we got in the shares, as the yesterday’s gains in the metal itself were rather modest, even though the chart patterns looked impressive.The CME’s Daily Delivery Report showed that 2 gold and 29 silver contracts were posted for delivery tomorrow.  The data isn’t even worth a cursory glance.There were no reported changes in either GLD or SLV.However, the U.S. Mint had a sales report yesterday.  They sold 3,500 ounces of gold eagles…1,000 one-ounce 24K gold buffaloes…and 493,000 silver eagles.  Month-to-date the mint has sold 46,500 ounce of gold eagles…8,500 one-ounce 24K gold buffaloes…and 2,568,000 silver eagles.The Comex-approved depositories showed that they received 797,388 troy ounces of silver on Friday…and shipped 740,519 ounces of the stuff out the door.  The link to that activity is here.Well, Nick Laird dropped a bomb on me last night.  I’d been waiting impatiently for the second quarter derivatives report from the Office of the Comptroller of the Currency…and it was posted yesterday.  Table 9 on Page 33 tells us a lot about what’s going on in the precious metals derivatives market.  But the shocker was that instead of including the top 5 U.S. banks, this report only shows the top 4 U.S. banks.  They dropped off HSBC…the second largest precious metals derivatives holder.  I’m sure they still hold these derivatives, but they’re no longer in this report…and Nick’s graph below reflects that.  All his data comes from that table on that page.(Click on image to enlarge)After exchanging a couple of e-mails on this issue, I finally came up with the reason why Table 9 [and a bunch of others] may be down to four banks…and here it is:Hi Nick,If you check Table 1 on page 25, you’ll see that the ‘big 4’ U.S. banks hold 93% of all the derivatives in the U.S. banking system…and HSBC in No. 5 spot, despite the fact that it holds a huge derivatives position in the precious metals, is now small potatoes in the grand scheme of things at only $4.47 trillion…1.96% of the total.As you said, you just checked it’s history and when they OCC started, they had 9 top banks in Table 9…then 7 – then 6 – then 5, and now 4…and that’s probably the reason why we’re down to 4 banks.  The rest are basically immaterial.  Ed93% of all derivatives in the U.S. banking system are held by 4 banks.  They are JPMorgan, Citibank, Bank of America, Goldman Sachs…and in very distant fifth position is HSBC USAI have the usual number of stories for a Tuesday…and that’s quite a few.David Stockman had it dead right. The safest investment strategy today is indeed the ABCD – Anything Bernanke (Draghi, King, Carney, Stevens et al) Cannot Destroy – approach.That’s why the Asians are buying Gold. That’s why the Europeans and increasing numbers of people in the English-speaking world are buying Gold. That’s why even central banks are buying Gold. Very few are selling physical Gold right now. But they are selling (and shorting) paper claims to the stuff. Bernanke can destroy those, but he can’t touch the real thing. – Bill Buckler, Gold This Week…22 June 2012It’s impossible to tell whether the price rallies during the New York trading session yesterday were short covering or new longs being placed…but if I had to bet a dollar, I’d guess that it was new longs being place in gold…and short covering in silver…and that’s just a guess.  I’ve stopped looking at the daily open interest numbers, because I’ve learned from hard experience that you can’t rely on them.  But one thing is for sure, is that Monday’s data will be in Friday’s Commitment of Traders Report.Of course I read Ted Butler’s weekend commentary with great interest…and he mentioned something that I thought was worth pointing out.  He said that “the weekly closes were the lowest of the year, with silver’ weekly closing being the lowest since the fall of 2010.” I always look at the daily charts for both silver and gold…and never the weekly charts, so I thought that maybe I should.  The 3-year weekly silver chart was a sight to behold…(Click on image to enlarge)Based on the RSI, silver is the most oversold on a weekly basis, than it has been at any point in the last three years…and by a very wide margin.  If that isn’t a screaming buy signal, I don’t know what is.  Too bad this chart didn’t go back another couple of years to take in the ‘crash’ of 2008.As a comparison, here’s the same 3-year weekly chart for gold…(Click on image to enlarge)Gold is oversold on a weekly basis as well, but nothing like silver…and that’s all because of the unprecedented scale of the price management scheme run by JPMorgan et al.Today, at the close of Comex trading at 1:30 p.m. Eastern time, is the cut-off for this Friday’s Commitment of Traders Report.  So I expect that whatever happens in today’s price action, should be in Friday’s report…unless the volume data is not reported in a ‘timely manner’, which is another little trick that ‘da boyz’ use to their advantage at times.Neither gold nor silver did very much in Far East trading on their Tuesday…and trading has been uneventful in London for the first couple of hours as well.  Net volume in both metals is shockingly low for this time of day…and the dollar index is comatose as well.  As I hit the ‘send’ button at 5:05 a.m. Eastern time, both metals are down a hair from Monday’s close.It’s too quiet out there…and I wonder what the Comex trading session will bring today?See you here tomorrow.last_img read more

Gold 131580 128610 171550

first_img Gold 1,315.80 1,286.10 1,715.50 Gold Junior Stocks (GDXJ) 36.40 39.46 96.12 Silver 21.87 21.18 32.25 Rock & Stock Stats Last One Year Ago Silver Stocks (SIL) 12.50 12.92 25.25 TSX Venture 955.33 942.04 1,321.29 Dear Reader, Greetings from Puerto Rico. For once, I’m not kicking rocks, but checking out what our International Man has identified as potentially the best alternative to expatriation for US taxpayers looking to legally reduce one’s tax obligations. So, I’m hard at work, but I confess I brought my wife, and we have managed to go diving—if folks are going to consider moving to a US territory off the beaten path, there have to be some good perks to make the stay pleasant, and not just economic. More on this via our International Man service. But speaking of other Casey services, one fact about readers of our metals publications is that many of them are seniors or people close to retirement age. Such people often wonder about the appropriateness of the kind of strategies and investments we recommend in BIG GOLD, Casey International Speculator and Casey Investment Alert. It’s a fair line of inquiry, so we’ve brought our best expert in to answer some questions. I hope you find our interview with Dennis Miller as entertaining as it is insightful and useful. Sincerely,center_img TSX (Toronto Stock Exchange) 13.327.46 12,847.44 12,499.76 Copper 3.28 3.27 3.55 Oil 94.61 102.04 87.09 One Month Ago Gold Producers (GDX) 24.08 24.41 52.01 Louis James Senior Metals Investment Strategist Casey Researchlast_img read more

As a kid Molly Easterlin loved playing sports Sh

first_imgAs a kid, Molly Easterlin loved playing sports. She started soccer at age four, and then in high school, she played tennis and ran track. Sports, Easterlin believes, underlie most of her greatest successes. They taught her discipline and teamwork, helped her make friends and enabled her to navigate the many challenges of growing up.When Easterlin became a pediatrician, she started seeing a lot of kids suffering from trauma, from physical abuse to emotional neglect. Many of these kids didn’t respond fully to traditional treatment for trauma and depression. Frustrated and searching for answers, Easterlin turned to her own past. “I suspected that sports might have a powerful impact [on kids],” she says. Easterlin wanted to know: Could sports improve the lives of people with trauma the way they’d improved hers?Her research, published Tuesday in JAMA Pediatrics, finds that, in short, yes: Participation in team sports as a young person can significantly reduce the long-term likelihood of depression and anxiety for people with childhood trauma. But according to Easterlin and other experts, the growing cost of youth team sports means that they can be off-limits to those who may need them most, kids living in poverty.In the burgeoning U.S. youth sports industry, many sports now require steep fees for participation, a factor that limits lower-income kids’ ability to participate. This trend, known as “pay to play” sports programming, is allowed in 49 states.Earlier research has shown that traumatic events in childhood, called adverse childhood experiences (ACEs) by public health researchers, contribute to social and physical problems throughout life, from obesity to chronic depression. ACEs are also common: About 50% of people have had at least one, and the more you have the more likely you are to have long-term health effects. To analyze how team sports impact the health of people who’ve experienced childhood adversity, Easterlin and her colleagues analyzed data from 9668 teens who participated in the National Longitudinal Study of Adolescent to Adult Health. They honed in on about 5,000 teens who had reported one or more ACEs. The kids were assessed first in 1994-1995 when they were in 7th-12th grade, and asked whether they participated (or planned to participate) in team sports. Fourteen years later, in 2008, these same people, now adults, were asked whether they had ever received a diagnosis of depression or anxiety. They were also tested for depressive symptoms in case they just hadn’t been diagnosed.Easterlin found that kids who had participated in team sports were significantly less likely to receive a diagnosis of depression or anxiety, and less likely to test positive for depressive symptoms. The findings were stronger for boys than for girls, but Easterlin says this may be in part because at the time of the initial data collection — 1994 — girls’ sports were less well-funded and supported than they are today.Easterlin and her colleagues also looked at participation in non-athletic school clubs, like drama and orchestra. These groups did not protect kids with ACEs against depression and anxiety the way that sports did in her study. That doesn’t mean these activities definitely aren’t helping, she says, but they didn’t capture an effect in their research. The study also doesn’t pinpoint exactly why sports may help, but Easterlin thinks teamwork may be a key.”There may be something powerful about that team environment [in sports], where you’re in competition, being coached in a certain way and interacting with your teammates towards a common goal,” she says.Christina Bethell, a professor at the Bloomberg School of Public Health at Johns Hopkins University with a focus on child well-being and adversity, says the study is a useful contribution to the study of ACEs. Bethell was not involved in the research. “Protective factors [for kids with trauma] are important to identify,” she says. “Sports is one such factor.”But, she says, it’s important to consider additional factors when examining resilience, like emotional connection with relatives and a sense of safety and support. These “family factors” may increase a person’s overall well-being, in addition to their ability to participate in sports. So sports might not be the sole cause of the protective effect. However, exercise is healthy regardless and “is clearly a priority” for developing kids, so we should be encouraging it anyway, she says.Bethell also notes that the study did not distinguish between kids with one ACE from kids with multiple ACEs: for kids with more ACEs, she thinks the effect of team sports likely would have been even more powerful. Amanda Paluch, a postdoctoral fellow at Northwestern University’s Feinberg School of Medicine, highlights the study’s novelty and potential impact. “In terms of a longitudinal study, this [association] has not been looked at much at all,” says Paluch, who wrote the study’s associated editorial.But, she says, “It is frustrating to think that those who may need [sports] most are less likely to have access to [them].”Though ACEs occur across income levels, kids raised in low-income families are more likely to have more of them. Additionally, adolescents who experienced childhood trauma were more likely to have parents with lower educational attainment and to live in single-parent households, both factors associated with low income.Less money, increasingly, has meant reduced access to sports and physical activity in the U.S. According to a 2018 report by the Aspen Institute, kids from families with household incomes less than $50,000 a year have reduced their sports participation over the last decade, while white kids from wealthier households have increased participation. Kids from lower income brackets participate in team sports at half the rate of their wealthier peers.To address this lack of access, Petruch and Easterlin say, policymakers and child health advocates should find ways to boost sports participation for kids, particularly those most at risk of childhood trauma. About half of American kids report some kind of ACE; conversely, depression is the leading cause of disability worldwide, often contributing to other diseases both physical and mental.With so many potential benefactors, Petruch points out, why not increase access to a treatment that’s fun, low-cost and ultimately far less painful than many other kinds of interventions?”[Team sports] could be a low-hanging fruit to address mental health outcomes,” she says. “Something that is so enjoyable…could be an important part of every kids’ life.”Susie Neilson is an intern on NPR’s Science Desk. Find her on Twitter at @susieneilson. Copyright 2019 NPR. To see more, visit read more

Thiazide use linked with reduced risk of low energy fractures in people

first_imgRelated StoriesSleep decline in one’s 50s, 60s increases risk of Alzheimer’s diseaseArtificial DNA can help release active ingredients from drugs in sequenceStudy finds sex-specific differences in risk and progression of Alzheimer’s diseaseLong-term use of thiazides reduced the risk of low energy fractures in people with Alzheimer’s disease. Photographer: Raija TörrönenHip fracture was the most common low energy fracture in the study population, and the risk of this fracture type decreased by 30% in long-term thiazide use. The association may be related to the fact that thiazides decrease urinary calcium excretion and increase bone mineral density, which may decrease the risk of fracture in case of a fall. Persons with Alzheimer’s disease have an increased risk of falling, as the disease leads to problems in balance and spatial orientation.The association of thiazide use and a reduced risk of low energy fractures disappeared in approximately one month after the use was discontinued. Thiazides are used in the treatment of hypertension. In this study, thiazide use was taken into account also when these drugs were combined with other antihypertensive drugs in the same tablet. Thiazides cannot be recommended for the prevention of fractures, as their use is known to be associated with postural hypotension and consequent falls.The study was based on the nationwide register-based MEDALZ study conducted at the University of Eastern Finland. For this study, 10,416 community-dwelling persons diagnosed with Alzheimer’s disease who had a low energy fracture were included and compared with 31,099 matched controls without a fracture. Apr 23 2019The use of thiazide diuretics was associated with a decreased risk of low energy fractures in people with Alzheimer’s disease, a new study from the University of Eastern Finland shows. The association was found in long-term use exceeding three years; however, shorter term use did not reduce the risk of fractures. Thiazides are typically prescribed to treat hypertension. The results were published in Osteoporosis International. Source: read more

Innovative system for treating type 1 diabetes mellitus

first_img Source: Reviewed by Alina Shrourou, B.Sc. (Editor)May 10 2019Type 1 diabetes mellitus (DMT1) contributes to 10% of the total of cases of diabetes mellitus worldwide, mainly in young people and is regarded as a growing health risk. DMT1 is characterized by the self-immune destruction of the pancreatic cells that produce insulin (pancreatic islets), which leads to severe insulin deficiency and which is followed by the raising of blood glucose levels. Right now, the therapy based on insulin injections is the treatment applied in type 1 diabetic patients. However, in addition to the medical complications this means in the long term, this treatment requires multiple daily measurements of blood glucose and the lifelong sub-cutaneous administration of insulin.Alternatively, “the transplant of isolated pancreatic islets from donors provides a fresh source of insulin-producing cells capable of meeting insulin requirements in accordance with blood glucose levels in patients with DM1. One of the drawbacks of islet transplants is the long-term use of immunosuppressant drugs to prevent the immune rejection of the transplanted islets; these drugs lower the patient’s defenses and entail serious medical complications”, explained the author of the work Albert Espona-Noguera. “To avoid this problem,” he went on, “the pancreatic islets can be isolated from the patient’s immune system by means of microencapsulation techniques in which the islets are encapsulated in microcapsules made of biocompatible (non-toxic) materials. Among many materials used in cell microencapsulation, alginate is the most widely used one. This natural polymer has excellent properties for biomedical applications as it offers high compatibility and low toxicity.” However, “the microencapsulation technique has various technical obstacles that are hampering its clinical application. A crucial problem is the high number of empty microcapsules generated during the process to microencapsulate the islets, which leads to a large increase in the volume of microcapsules to be implanted, and which in turn may increase the host’s immune reaction following implantation,” said Espona-Noguera.Related StoriesStudy: Antidepressants reduce mortality by 35% in patients with diabetesNew biomaterial could encapsulate and protect implanted insulin-producing cellsDiabetes patients experiencing empathy from PCPs have beneficial long-term clinical outcomesInnovative system of magnetic separationIn order to avoid the high number of empty microcapsules, “we have come up with an innovative approach for purifying the microencapsulated islets in order to reduce the implant volume by separating the microencapsulated islets from the empty microcapsules”, explained the researcher at the UPV/EHU-Ciber BNN which is part of the Nanbiosis ICTS (Singular Scientific and Technological Infrastructure). “We have developed a system to magnetically separate the microcapsules and which combines different technologies: magnetic nanoparticles and a microfluidic chip, in other words, a chip with channels of micrometric size produced by means of 3D printing techniques and which contains strategically placed magnets,” added the researcher. “To separate the microcapsules, the pancreatic islets are put into contact with magnetic nanoparticles, thus providing them with magnetic properties.After that, the islets are microencapsulated, thus obtaining capsules containing magnetic islets and non-magnetic empty capsules. When the microcapsules are pumped through the chip’s microchannels, the magnets move the magnetic capsules towards the exit microchannel, while the non-magnetic empty ones make their way through another exit microchannel,” he specified. That way “we are able to eliminate the empty capsules and, as a result, we reduce the volume of the therapeutic microcapsule implant. The great purification efficiency of this magnetic separation system has enabled us to lower the implant volume by nearly 80%, thus reducing the complications arising out of the implanting of large volumes of microcapsules and providing us with an alternative DMT1 treatment”, stressed Espona-Noguera.In addition, “in this work we studied the functionality of the purified implants in diabetic animal models. We saw that following subcutaneous implanting of the microencapsulated islets in diabetic animals, the blood glucose levels returned to normal levels for nearly 17 weeks”, he added.last_img read more